NBA 2k15 "Injuries 2.0" System Details

With “Injuries 2.0”, every player has a unique durability rating for 16 different body parts (think left foot, right foot, left ankle, right ankle, etc.). This level of control allows us to pick a player like Russell Westbrook and say that he has a right knee with a significantly higher chance of getting injured than his left knee, or any other body part for that issue.

NBA 2k15 'Injuries 2.0' System Details : Realistic Injuries

In short, player injuries are going to be a lot more relevant, and a lot less random.